Bicarbonate
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Insulin is used for significant neonatal hyperglycemia if other key steps fail – lowering the intravenous glucose infusion rate, treating underlying condition (e.g. sepsis).
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The intraventricular hemorrhage in the preterm infants usually originates in the germinal matrix (temporary developmental structure with significant vascular supply due to massive mitotic and metabolic activity). The structure is divided from the cerebral ventricles only by a thin layer of subependymal cells and disappears after 34 weeks of gestation – one…
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Retinopathy of prematurity (ROP) is a vasoproliferative disorder (fibrovascular proliferation) of developing retina in preterm infants. It is characterised by disorganized growth of abnormal new blood vessels (=> hemorrhage) and fibrous tissue ( => contracted scar tissue causing retinal detachment). Incidence of ROP is inversely proportional to the gestational age (general ROP screening…
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Glucose Infusion Rate (GIR) is the speed at which intravenous glucose is given to a newborn to treat hypoglycemia (low blood sugar) – standard starting target = 4-6 mg/kg/min.
Apnea
Apneas represent another important group of respiratory/ventilation dysfunctions in newborns (apart from perinatal asphyxia and respiratory distress syndrome). They are generally defined as a cessation of breathing movements and air flow for more than 20 seconds, thus often being accompanied by desaturation and bradycardia. Spontaneous breathing causes water in lungs to be resorbed into blood and…
Persistent ductus arteriosus
Persistent ductus arteriosus (PDA) connects aorta with main pulmonary artery (MPA) (or left pulmonary artery – LPA) and during fetal life serves as important right-left shunt => mixed blood flowing from the pulmonary artery to the descendant aorta and supplying the lower half of the body. PDA prenatally remains open due to low partial pressure…
