Surfactant

  • Neonatal Respiratory Distress

    Learning outcomes Introduction Successful postnatal transition depends on a rapid cascade of physiological milestones: When any part of this process falters, neonatal respiratory distress develops—clinically defined by any change to frequency and/or quality of breathing pattern (i.e. abnormal breathing rates or increased work of breathing). A normal neonatal respiratory rate…

  • Oxygen Therapy

    We should attempt to maintain normoxemic oxygenation in order to prevent hypoxic injury (mainly in the cerebral tissue). On the other hand, oxygen should be carefully titrated to newborns, especially preterm, due to the negative effects associated with its overuse (reactive oxygen species = ROS).  Hyperoxia induces the production of oxygen radicals that subsequently trigger…