Polycythemia

Polycythemia

Polycythemia is defined by venous hemoglobin concentration > 220 g/l or by hematocrit value > 0.65 during the first week of life. It correlates clinically with hyperviscosity syndrome. The common causes: chronic intrauterine hypoxia twin-twin transfusion syndrome in monochorionic-diamniotic twins (recipient twin) excessive placental transfusion Diagnosis Clinical signs dictated by the severity of hyperviscosity syndrome (infant…

Thrombophilia

Thrombophilia

Neonatal thrombophilia can cause both arterial and venous thromboembolic events. Thrombophilia results from the disrupted hemostatic system┬áthat normally consists of 4 integrated components: the coagulation system, endothelium and regulatory proteins, platelets, and fibrinolysis. The peak incidence of pediatric thromboembolic events occurs in neonates and infants < 1 year of age….