Polycythemia

  • Polycythemia

    Polycythemia is defined by venous hemoglobin concentration > 220 g/l or by hematocrit value > 0.65 during the first week of life. It correlates clinically with hyperviscosity syndrome. The common causes: chronic intrauterine hypoxia twin-twin transfusion syndrome in monochorionic-diamniotic twins (recipient twin) excessive placental transfusion Diagnosis Clinical signs dictated by the severity of hyperviscosity syndrome (infant…

  • Thrombophilia

    Neonatal thrombophilia can cause both arterial and venous thromboembolic events. Thrombophilia results from the disrupted hemostatic system that normally consists of 4 integrated components: the coagulation system, endothelium and regulatory proteins, platelets, and fibrinolysis. The peak incidence of pediatric thromboembolic events occurs in neonates and infants < 1 year of age….