Hematology

Hyperbilirubinemia

Hyperbilirubinemia is defined as serum bilirubin concentration > 25 μmol/l. However, clinical presentation (jaundice (icterus) – yellowish colouring of the skin, sclera and mucosa) is apparent in …

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Anemia

Hemoglobin production begins around the third week of pregnancy in the cytoplasm of embryonic red blood cells in the yolk sac. Hematopoietic stem cells then colonize other …

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Polycythemia

Polycythemia is defined by venous hemoglobin concentration > 220 g/l or by hematocrit value > 0.65 during the first week of life. It correlates clinically with hyperviscosity syndrome. The …

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Leucocyte abnormalities

There are significant differences in white blood cell (WBC) total and differential counts between newborns and older children. Alterations in WBC total and differential count can be …

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Coagulation disorders

Newborns (preterm in particular) have relatively low levels of pro-coagulation factors (vitamin K dependent factors), diminished platelet functions (their levels are similar to adults), as well as low anti-coagulation factors (antithrombin …

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Trombophilia

Inherited thrombophilia permanent condition that can increase the risk for thrombosis formation in presence of other factors or triggers (see acquired conditions below) Leiden mutation of …

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