Congenital anomalies of nervous system

Congenital anomalies of nervous system

Congenital anomalies of nervous system can be detected by the prenatal screening (ultrasound – hydrocephalus, anencephalus; biochemistry using alpha-fetoprotein (AFP) – elevated in amniotic fluid and maternal serum in neural tube defects).  Postnatal investigations include proper clinical examination (proper head circumference measurement, neurologic symptoms, septic workup) and imaging (cranial ultrasound, magnetic resonance imaging…

Neurodevelopment

Neurodevelopment

The central nervous system of extremely preterm infants is highly susceptible to perinatal injuries due to the presence of immature vasculature in the germinal matrix and periventricular white matter. Furthermore, the sensitivity of cerebral tissue to hypoxia-ischemia stems from already low baseline CBF and high oxygen consumption with increased oxygen extraction. In…